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(E/Z)-GO289
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(E/Z)-GO289图片
CAS NO:694522-87-7
包装与价格：
包装价格(元)
5mg电议
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25mg电议
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产品介绍
(E/Z)-GO289 是一种有效且选择性的酪蛋白激酶 2 (CK2) 抑制剂 (IC50=7 nM)。(E/Z)-GO289 强烈延长昼夜节律周期。(E/Z)-GO289 表现出与细胞时钟功能相关的对癌细胞生长的细胞类型依赖性抑制。
Cas No.694522-87-7
分子式C17H15BrN4O2S
分子量419.3
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1]. (E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].

[1]. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.