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BMS-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS-1图片
CAS NO:1675201-83-8
规格:≥98%
包装与价格:
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 475.58
Formula C29H33NO5
CAS No. 1675201-83-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 95 mg/mL (199.7 mM)
Water: 95 mg/mL (199.7 mM)
Ethanol: N/A
SMILES CodeO=C([C@H]1N(CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC)CCCC1)O
SynonymsPD1/PDL1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD1-PDL1-IN1; BMS-1; BMS 1; BMS1
实验参考方法
In Vitro

In vitro activity: PD1-PDL1 inhibitor 1 (also known as PD1-PDL1-IN1, or PD1/PD-L1 inhibitor 1) is a small molecule inhibitor of PD-1/PD-L1 protein/protein interaction with IC50 of 6 nM. It was first discovered by BMS (Bristol-Myers-Squibb) as an immunomodulator for the Programmed death-ligand 1 (PD-L1) with potential anticancer activities. PD-L1 is known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. It is reported that the overexpression of PD-L1 may allow cancers to escape the surveilance of host immune system.


Kinase Assay: The HTRF PD1/PD-L1 Binding Assay is designed to measure the interaction between PD1 and PD-L1 proteins. Utilizing HTRF (Homogeneous Time-resolved Fluorescence) technology, the assay enables simple and rapid characterization of compound and antibody blockers in a high throughput format.

In VivoNA
Animal modelNA
Formulation & DosageNA
References J Med Chem. 2017 Jul 13;60(13):5857-5867.