| CAS NO: | 2247911-68-6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 2247911-68-6 |
| Canonical SMILES | OC(C1=C(OC)C(C2=CC=CN=C2OC)=CN=C1OC)C3=CC=C(C=CC=C4)C4=C3 |
| 分子式 | C24H22N2O4 |
| 分子量 | 402.4 |
| 溶解度 | DMF: 30mg/mL,DMSO: 30mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 µM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 . 1.Brand, S., Roy, S., SchrÖder, P., et al.Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathwaysCell Chem. Biol.25(9)1095-1106(2018) |
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