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DLK-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DLK-IN-1图片
CAS NO:1620574-24-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
DLK-IN-1是双亮氨酸拉链激酶(DLK,MAP3K12)的选择性抑制剂，其Ki值为3nM。DLK-IN-1保持着良好的中枢神经系统穿透能力，并且在脑内剂量过量后依旧耐受性良好，在阿尔兹海默症动物模型中有良好的活性。
Cas No.1620574-24-4
Canonical SMILESCC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C
分子式C20H24F3N5O2
分子量423.43
溶解度DMSO : 62.5 mg/mL (147.60 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer's Disease.

[1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.