从镰刀菌毒素中分离出的 Enniatin A1 是一种环状六肽，由交替的 D-α-羟基异戊酸和 N-甲基-L-氨基酸组成。 Enniatin A1 通过诱导细胞凋亡和破坏 ERK 信号通路而具有抗癌特性。 Enniatin A1 在大鼠肝微粒体中抑制 ACAT，IC50 为 49 μM。
| Cas No. | 4530-21-6 |
| 别名 | 恩镰孢菌素 A1 |
| Canonical SMILES | C[C@@H](CC)[C@]([H])(N(C)C([C@@H](C(C)C)OC([C@H]([C@H](CC)C)N(C)C1=O)=O)=O)C(O[C@]([H])(C(C)C)C(N(C)[C@@H](C(C)C)C(O[C@@H]1C(C)C)=O)=O)=O |
| 分子式 | C35H61N3O9 |
| 分子量 | 667.9 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A1 is one of four major analogs in the enniatin complex . Its ionophoric activity has been described. Additionally, enniatin A1 has been found to induce apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation. |
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