| CAS NO: | 1216739-35-3 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1216739-35-3 |
| 别名 | 布美他尼 d5 |
| Canonical SMILES | CCCCNC1=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(N)(=O)=O)=CC(C(O)=O)=C1 |
| 分子式 | C17H15D5N2O5S |
| 分子量 | 369.4 |
| 溶解度 | DMF: 33 mg/ml,DMSO: 25 mg/ml,Ethanol: 14 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bumetanide-d5is intended for use as an internal standard for the quantification of bumetanide by GC- or LC-MS. Bumetanide is a loop diuretic with good absorption and pharmacodynamic properties.1,2It acts as an inhibitor of the Na-K-Cl cotransporter 1 (NKCC1) and the kidney-specific NKCC2 (Kis = 0.5 and 59 μM for human and rabbit NKCC1, respectively).3,4Bumetanide also inhibits several isoforms of carbonic anhydrase.5 1.Ramsay, L.E., McInnes, G.T., Hettiarachchi, J., et al.Bumetanide and frusemide: A comparison of dose-response curves in healthy menBr. J. Clin. Pharmacol.5(3)243-247(1978) 2.Marcantonio, L.A., Auld, W.H.R., Murdoch, W.R., et al.The pharmacokinetics and pharmacodynamics of the diuretic bumetanide in hepatic and renal diseaseBr. J. Clin. Pharmacol.15(2)245-252(1983) 3.Horster, M.Embryonic epithelial membrane transportersAm. J. Physiol. Renal Physiol.279(6)982-996(2000) 4.Gillen, C.M., Brill, S., Payne, J.A., et al.Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter familyJ. Biol. Chem.271(27)16237-16244(1996) 5.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008) |
m.cnreagent.com