CAS NO: | 1215541-47-1 |
包装: | 1mg |
市场价: | 4460元 |
Cas No. | 1215541-47-1 |
别名 | 西洛他唑-D4,OPC-13013-d4 |
Canonical SMILES | O=C(N1)CCC2=C1C=CC(OCCCCC3=NN=NN3C4C([2H])([2H])CCCC4([2H])[2H])=C2 |
分子式 | C20H23D4N5O2 |
分子量 | 373.5 |
溶解度 | DMSO: Slightly soluble,Methanol: Slightly soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Cilostazol-d4is intended for use as an internal standard for the quantification of cilostazol by GC- or LC-MS. Cilostazol is a phosphodiesterase 3A (PDE3A) inhibitor (IC50= 0.2 µM for the platelet enzyme).1It is selective for PDE3A over PDE1, -2, -4, and 5 (IC50s = >5 µM for all). Cilostazol inhibits collagen- or ADP-induced aggregation of isolated rabbit platelets (IC50s = 29 and 31 µM, respectively).2In vivo, cilostazol (30 mg/kg) reduces thrombus formation by 84% in a mouse model of pulmonary thromboembolism. It reduces cardiac fibrosis and prevents the development of diastolic dysfunction and cardiac hypertrophy induced by a high-fat diet and angiotensin II in mice.3Formulations containing cilostazol have been used in the treatment of the symptoms of intermittent claudication in peripheral vascular disease. 1.SchrÖr, K.The pharmacology of cilostazolDiabetes Obes. Metab.4 (Suppl 2)S14-S19(2002) 2.Koga, Y., Kihara, Y., Okada, M., et al.2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activitiesBioorg. Med. Chem. Lett.8(12)1471-1476(1998) 3.Reddy, S.S., Agarwal, H., and Barthwal, M.K.Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive miceJ. Mol. Cell. Cardiol.12346-57(2018) |