MK2-IN-3

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MK2-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

724711-21-1

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

MK2-IN-3 是一种有效和选择性的 MAPKAP-K2 (MK-2) 抑制剂，IC50 值为 8.5 nM。MK2-IN-3 对 MK-3，MK-5，ERK2，MNK1，p38a (IC50=0.21, 0.081, 3.44, 5.7, >100 µM) 和 MSK1，MSK2，CDK2，JNK2，IKK2 (IC50>200 µM) 表现出良好的选择性。MK2-IN-3 可以减少 U937 细胞和体内 TNFα 的产生。

Cas No.	724711-21-1
Canonical SMILES	O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1
分子式	C₂₁H₁₆N₄O
分子量	340.38
溶解度	DMSO : 62.5 mg/mL (183.62 mM)
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 µM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 µM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo[1]. MK2-IN-3 (compound 16) inhibits MK-2 and TNFα production in U937 cells, with IC50s of 8.5 nM and 4.4 µM, respectively[1]. MK2-IN-3 (compound 16) (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model[1]. References: [1]. Anderson DR, et, al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.