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Cearoin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cearoin图片
CAS NO:52811-37-7
包装:1mg
市场价:2250元

产品介绍
Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
Cas No.52811-37-7
别名2,5-二羟基-4-甲氧基二苯甲酮
Canonical SMILESO=C(C1=CC(O)=C(OC)C=C1O)C2=CC=CC=C2
分子式C14H12O4
分子量244.24
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].

Cearoin (10-80 µM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 µM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 µM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].

References:
[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.