| CAS NO: | 72214-67-6 |
| 包装: | 5mg |
| 市场价: | 1121元 |
| Cas No. | 72214-67-6 |
| 别名 | (2,4-二氯苯基)甲基硫基甲烷脒盐酸盐 |
| 分子式 | C8H9Cl3N2S |
| 分子量 | 271.59 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities[1]. RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro[1].RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells[1]. RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours)[1].RRD-251 alters the expression of cell cycle and apoptosis regulatory protein[1]. RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas[1]. [1]. Sandeep Singh, et al. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Mol Cancer Ther. 2010 Dec; 9(12): 3330-3341. |
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