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EM-12
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
EM-12图片
CAS NO:26581-81-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
EM-12 (EM-12) 是一种致畸的沙利度胺类似物，比沙利度胺更活跃，水解更稳定。 EM-12 增强大鼠结肠腺癌的 1,2-二甲基肼诱导。
Cas No.26581-81-7
别名EM-12
Canonical SMILESO=C1NC(C(CC1)N2C(C3=CC=CC=C3C2)=O)=O
分子式C13H12N2O3
分子量244.2
溶解度DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EM-12 is a derivative of thalidomide with teratogenic activity.1Intravenous administration of EM-12 (150 mg/kg) to pregnant females induces fetal resorption and skeletal malformation in surviving offspring in rats, rabbits, and rhesus monkeys. Dietary administration of EM-12 (12% w/w) enhances 1,2-dimethylhydrazine-induced colonic adenocarcinoma formation in rats.2

1.Schumacher, H.J., Terapane, J., Jordan, R.L., et al.The teratogenic activity of a thalidomide analogue, EM12 in rabbits, rats, and monkeysTeratology5(2)233-240(1972) 2.Gershbein, L.L.The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomasCancer Lett.60(2)129-133(1991)