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S-(1,2-Dichlorovinyl)-Cysteine(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-(1,2-Dichlorovinyl)-Cysteine(hydrochloride)图片
CAS NO:2508026-62-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A nephrotoxin and metabolite of trichloroethylene
Cas No.2508026-62-6
Canonical SMILESCl/C=C(Cl)\SC[C@H](N)C(O)=O.Cl
分子式C5H7Cl2NO2S • HCl
分子量252.5
溶解度DMSO: soluble,Methanol: soluble,Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

S-(1,2-Dichlorovinyl)-cysteine (hydrochloride) is a nephrotoxin and metabolite of trichloroethylene.1,2,3It is formedviaa dichlorovinyl glutathione intermediate and its subsequent cleavage by dipeptidase.1S-(1,2-Dichlorovinyl)-cysteine (hydrochloride) (1 mM) is cytotoxic to isolated human renal proximal tubule cells. It increases urine levels of N-acetyl-β-D-glucosaminidase, total protein, and glucose in rabbits when administered at a dose of 10 mg/kg.2S-(1,2-Dichlorovinyl)-cysteine (hydrochloride) induces renal necrosis and lethality in rats (LD50s = 66-83 mg/kg).3

1.Cummings, B.S., and Lash, L.H.Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cellsToxicol. Sci.53(2)458-466(2000) 2.Davis, J.W., Blakeman, D.P., Jolly, R.A., et al.S-(1,2-dichlorovinyl)-L-cysteine-induced nephrotoxicity in the New Zealand white rabbit: Characterization of proteinuria and examination of the potential role of oxidative injuryToxicol. Pathol.23(4)487-497(1995) 3.Terracini, B., and Parker, V.H.A pathological study on the toxicity of S-dichlorovinyl-?-cysteine Food Cosmet. Toxicol.367-74(1965)