| CAS NO: | 675126-09-7 |
| 包装: | 1mg |
| 市场价: | 2646元 |
| Cas No. | 675126-09-7 |
| Canonical SMILES | N[C@@H]1CC[C@H](C2=CC(Cl)=C(C=C2)Cl)C3=C1C=CC=C3.Cl |
| 分子式 | C16H15Cl2N • HCl |
| 分子量 | 328.7 |
| 溶解度 | DMSO: slightly,Methanol: slightly |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-desmethyl Sertraline is a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline .1It is formed from sertraline primarily by the cytochrome P450 (CYP) isoform CYP2B6 and to a lesser extent by CYP2C19, -2C9, -2D6, and -3A in human liver microsomes. N-desmethyl Sertraline has been found in wastewater effluent.2 1.Obach, R.S., Cox, L.M., and Tremaine, L.M.Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: An in vitro studyDrug Metab. Dispos.33(2)262-270(2005) 2.Lajeunesse, A., Gagnon, C., and SauvÉ, S.Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometryAnal. Chem.80(14)5325-5333(2008) |
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