| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| Canonical SMILES | OC(C1=CC=CC=C1O2)=C(C(CC(C)=O)C3=C([2H])C([2H])=C([N+]([O-])=O)C([2H])=C3[2H])C2=O |
| 分子式 | C19H11D4NO6 |
| 分子量 | 357.4 |
| 溶解度 | Acetonitrile: soluble,DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Acenocoumarol-d4is intended for use as an internal standard for the quantification of acenocoumarol by GC- or LC-MS. Acenocoumarol is an anticoagulant and vitamin K antagonist.1It inhibits the reduction of vitamin K1epoxide to vitamin K1by vitamin K1epoxide reductase (VKOR;IC50= 1.5 and 5.8 nM for VKORC1 and VKORC1L1, respectively).1Acenocoumarol also inhibits a variety of VKOR mutants in cell-based reporter assays (IC50s = 0.54-11.21 nM).2It prolongs prothrombin time in rat blood when administered at a dose of 1.5 mg/kg.3 1.Czogalla, K.J., Liphardt, K., HÖning, K., et al.VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sitesBlood Adv.2(6)691-702(2018) 2.Chen, X., Jin, D.-Y., Stafford, D.W., et al.Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieuBlood132(18)1974-1984(2018) 3.Meinertz, T., Kasper, W., Kahl, C., et al.Anticoagulant activity of the enantiomers of acenocoumarolBr. J. Clin. Pharmacol.5(2)187-188(1978) |
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