| CAS NO: | 1185144-74-4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1185144-74-4 |
| 别名 | 奥美沙坦 d6 |
| Canonical SMILES | OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C1=C(C(O)=O)N(CC(C=C2)=CC=C2C3=C(C4=NN=NN4)C=CC=C3)C(CCC)=N1 |
| 分子式 | C24H20D6N6O3 |
| 分子量 | 452.5 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Olmesartan-d6is intended for use as an internal standard for the quantification of olmesartan by GC- or LC-MS. Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50= 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil .1It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma.2Olmesartan is selective for AT1over AT2(IC50= >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II but not phenylephrine or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats. 1.Mizuno, M., Sada, T., Ikeda, M., et al.Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonistEur. J. Pharmacol.285(2)181-188(1995) 2.Ishizuka, T., Fujimori, I., Nishida, A., et al.Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: Molecular identification and contribution to plasma metabolismDrug Metab. Dispos.40(2)374-380(2012) |
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