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Poziotinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Poziotinib图片
CAS NO:1092364-38-9
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品名称
HM781-36B, NOV120101, NOV-120101, NOV 120101
产品介绍

生物活性

Poziotinib是一种口服生物利用的,基于喹唑啉的泛表皮生长因子受体(EGFR或HER)抑制剂,具有潜在的抗肿瘤活性。

靶点信息

HER1HER2HER4
3.2 nM5.3 nM23.5 nM

化学数据

目录号A13044
作用机制Inhibitor (抑制剂)
M. Wt491.34
FormulaC23H21Cl2FN4O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1092364-38-9
SynonymsHM781-36B, NOV120101, NOV-120101, NOV 120101
SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C

溶解度

In vitro (25°C)DMSO84 mg/mL (170.96 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+40% PEG 300+2% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.35 mL101.76 mL203.53 mL
0.5 mM4.07 mL20.35 mL40.71 mL
1 mM2.04 mL10.18 mL20.35 mL
5 mM0.41 mL2.04 mL4.07 mL

*The above data is based on the productmolecular weight 491.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.