| 包装: | 1mg |
| 市场价: | 9058元 |
| 别名 | BIBR 953-13C,d3; BIBR 953ZW-13C,d3 |
| Canonical SMILES | OC(CCN(C1=CC=CC=N1)C(C2=CC=C(C(N=C3CNC4=CC=C(C=C4)C(N)=N)=C2)N3[13C]([2H])([2H])[2H])=O)=O |
| 分子式 | C24[13C]H22D3N7O3 |
| 分子量 | 475.5 |
| 溶解度 | Acidic solution: soluble,DMSO: 0.5 mg/ml (@*25°C ) |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dabigatran-13C-d3is intended for use as an internal standard for the quantification of dabigatran by GC- or LC-MS. Dabigatran is an inhibitor of thrombin (Ki= 0.0045 µM) and an active metabolite of the thrombin inhibitor prodrug dabigatran etexilate .1,2It also inhibits trypsin (Ki= 0.0503 µM) but is selective for thrombin and trypsin over plasmin, Factor Xa, activated protein C, and tissue plasminogen activator (tPA; Kis = 1.695, 3.76, 20.93, and 45.36 µM, respectively).1 1.Hauel, N.H., Nar, H., Priepke, H., et al.Structure-based design of novel potent nonpeptide thrombin inhibitorsJ. Med. Chem.45(9)1757-1766(2002) 2.Eisert, W.G., Hauel, N., Stangier, J., et al.Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombinArterioscler. Thromb. Vasc. Biol.30(10)1885-1889(2010) |
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