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AZD 2716
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AZD 2716图片
CAS NO:1845753-81-2
包装与价格：
包装价格(元)
5mg电议
25mg电议

产品介绍
An sPLA2inhibitor
Cas No.1845753-81-2
Canonical SMILESNC(C1=C(C2=CC(C[C@@H](C)C(O)=O)=CC=C2)C=C(C=C1)CC3=CC=CC=C3)=O
分子式C24H23NO3
分子量373.4
溶解度DMF: 16 mg/mL,DMSO: 10 mg/mL,Ethanol: 16 mg/mL,PBS (pH 7.2): 0.3 mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZD 2716 is an inhibitor of secretory phospholipase A2(sPLA2; IC50s = 0.01, 0.04, and 0.4 µM for sPLA2-IIa, -V, and -X, respectively).1It inhibits sPLA2activity in atherosclerotic plaque homogenates isolated from patients with coronary artery disease (IC50= 56 nM).

1.Giordanetto, F., Pettersen, D., Starke, I., et al.Discovery of AZD2716: A novel secreted phospholipase A2 (sPLA2) inhibitor for the treatment of coronary artery diseaseACS Med. Chem. Lett.7(10)884-889(2016)