| CAS NO: | 2749555-66-4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 2749555-66-4 |
| Canonical SMILES | O=S(N1C[C@@H](CCC1)C(N2CCC(F)(CC2)F)=O)(C3=CC=C(C=C3)S(C(C)C)(=O)=O)=O |
| 分子式 | C20H28F2N2O5S2 |
| 分子量 | 478.6 |
| 溶解度 | DMF: 2 mg/ml,DMSO: 3 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): insol |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DX3-213B is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50= 3.6 nM).1It inhibits the proliferation of MiaPaCa-2 cells cultured in galactose- but not glucose-containing media (IC50s = 9.1 and >3,000 nM, respectively). DX3-213B (10 mg/kg) reduces tumor volume in a Panc02 murine pancreatic ductal adenocarcinoma model. 1.Xue, D., Xu, Y., Kyani, A., et al.Multiparameter optimization of oxidative phosphorylation inhibitors for the treatment of pancreatic cancerJ. Med. Chem.65(4)3404-3419(2022) |
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