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BQ-3020(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BQ-3020(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
A peptide ETBreceptor antagonist
Canonical SMILESOC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式C96H140N20O25S • XCF3COOH
分子量2006.3
溶解度DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BQ-3020 is a peptide endothelin type B (ETB) receptor agonist.1It selectively binds to ETBover ETAreceptors (IC50s = 0.07 and 940 nM, respectively) and induces inositol triphosphate formation and calcium mobilization in isolated bovine carotid artery endothelial cells.1,2BQ-3020 increases or decreases renal perfusion pressure in Dahl salt-resistant or -sensitive rats, respectively.3It decreases the production of nitric oxide (NO) and induces vasoconstriction in a rat model of diet-induced hypercholesterolemia.

1.Ihara, M., Saek, T., Fukuroda, T., et al.A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptorsLife Sci.51(6)PL47-PL52(1992) 2.Hirata, Y., Emori, T., Eguchi, S., et al.Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cellsJ. Clin. Invest.91(4)1367-1373(1993) 3.Kakoki, M., Hirata, Y., Hayakawa, H., et al.Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidneyCirculation99(9)1242-1248(1999)