| CAS NO: | 220001-53-6 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 220001-53-6 |
| 别名 | 7-苄氧基-4-三氟甲基香豆素 |
| Canonical SMILES | O=C1OC2=C(C(C(F)(F)F)=C1)C=CC(OCC3=CC=CC=C3)=C2 |
| 分子式 | C17H11F3O3 |
| 分子量 | 320.3 |
| 溶解度 | DMF: 3 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol |
| 储存条件 | -20буC |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 7-Benzyloxy-4-(trifluoromethyl)coumarin (BFC) is a fluorogenic substrate for the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A.1,2Upon enzymatic cleavage by CYP1A2 or CYP3A, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP1A2 and CYP3A activity. HFC displays excitation/emission maxima of 410/510 nm, respectively. 1.Renwick, A.B., Surry, D., Price, R.J., et al.Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoformsXenobiotica30(10)955-969(2000) 2.Ducharme, J., Sevrioukova, I.F., Thibodeaux, C.J., et al.Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductaseBiochemistry60(28)2259-2271(2021) |
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