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BAY 2666605
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BAY 2666605图片
CAS NO:2275774-60-0
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂,IC50 分别为 87 nM 和 50 nM。BAY 2666605 是一种 PDE3A-SLFN12 复合诱导剂 (WO2019025562A1; example 135)。
Cas No.2275774-60-0
分子式C17H12F4N2O2
分子量352.28
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135)[1].

BAY 2666605 (example 135) has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer[1].

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer[1].

[1]. Manuel ELLERMANN, et al. Dihydrooxadiazinones. WO2019025562A1.