您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > YW3-56(hydrochloride)(technical grade)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
YW3-56(hydrochloride)(technical grade)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YW3-56(hydrochloride)(technical grade)图片
CAS NO:2309756-20-3
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
A PAD2 and PAD4 inhibitor
Cas No.2309756-20-3
Canonical SMILESCN(C)C1=CC=C2C(C=CC(C(N[C@@H](CCCNC(CCl)=N)C(NCC3=CC=CC=C3)=O)=O)=C2)=C1.Cl
分子式C27H32ClN5O2.HCl
分子量530.5
溶解度Methanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2

1.Wang, Y., Li, P., Wang, S., et al.Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activityThe Journal of Biological Chemisty287(31)25941-25952(2012) 2.Wang, S., Chen, X.A., Hu, J., et al.ATF4 gene network mediates cellular response to the anticancer PAD inhibitor YW3-56 in triple-negative breast cancer cellsMol. Cancer Ther.14(4)877-888(2015)