BIX NHE1 inhibitor 是有效的钠氢交换异构体 1 (NHE1) 抑制剂，在细胞内 pH 恢复 (pHi) 和人血小板肿胀试验中的 IC50 分别为 6 和 31 nM。
| Cas No. | 1422252-46-7 |
| Canonical SMILES | CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl |
| 分子式 | C16H19F3N4O2.HCl |
| 分子量 | 392.8 |
| 溶解度 | DMSO|19.64|50| |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable. |
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