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Ac-QPKK(Ac)-AMC
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ac-QPKK(Ac)-AMC图片
CAS NO:1387005-23-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A fluorogenic substrate for SIRT1, SIRT2, and SIRT3
Cas No.1387005-23-3
Canonical SMILESNCCCC[C@@H](C(N[C@H](C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)CCCCNC(C)=O)=O)NC([C@@H]3CCCN3C([C@H](CCC(N)=O)NC(C)=O)=O)=O
分子式C36H52N8O9
分子量740.9
溶解度DMSO: soluble,Ethanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3.1It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

1.Galleano, I., Schiedel, M., Jung, M., et al.A continuous, fluorogenic sirtuin 2 deacylase assay: Substrate screening and inhibitor evaluationJ. Med. Chem.59(3)1021-1031(2017)