生物活性
SCR7是一种特定的DNA Ligase IV抑制剂。SCR7通过激活p53介导的细胞凋亡来抑制多种细胞类型中双链断裂的末端连接，从而导致肿瘤消退。
化学数据
| 目录号 | A15447 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 334.39 |
| Formula | C18H14N4OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1533426-72-0 |
| Synonyms | SCR-7, SCR 7 |
| SMILES | O=C(C(/N=C/C1=CC=CC=C1)=C(/N=C/C2=CC=CC=C2)N3)NC3=S |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 29.91 mL | 149.53 mL | 299.05 mL |
| 0.5 mM | 5.98 mL | 29.91 mL | 59.81 mL |
| 1 mM | 2.99 mL | 14.95 mL | 29.91 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.98 mL |
*The above data is based on the productmolecular weight 334.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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