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653-47
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
653-47图片
CAS NO:1224678-75-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
653-47 是一种增强剂,能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。653-47 也是一种很弱的抑制剂,其 IC50 为 26.3 μM。
Cas No.1224678-75-4
分子式C20H19ClN2O3
分子量370.83
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].

[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.