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PHY34
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PHY34图片
CAS NO:2130033-55-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of late-stage autophagy
Cas No.2130033-55-3
Canonical SMILESO=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@H]6[C@@H]([C@]7([H])[C@](OC(C)(O7)C)([H])[C@H](O6)CO)O)=C2CO1
分子式C30H30O12
分子量582.6
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PHY34 is an inhibitor of late-stage autophagy.1It is cytotoxic to OVCAR-3 and OVCAR-8 ovarian cancer cells (IC50= 4 nM for both) and induces apoptosis in the same cells when used at a concentration of 100 nM. PHY34 increases the number of LC3B puncta and induces autophagosome accumulation in HeLa cells (EC50s = 1.99 and 3.86 nM, respectively). It reduces tumor growth in an OVCAR-8 mouse xenograft model when administered at a dose of 0.75 mg/kg.

1.Young, A.N., Herrera, D., Huntsman, A.C., et al.Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high-grade serous ovarian cancer by late-stage autophagy inhibitionMol. Cancer Ther.17(10)2123-2135(2018)