| CAS NO: | 1132819-16-9 |
| 包装: | 1mg |
| 市场价: | 11325元 |
| Cas No. | 1132819-16-9 |
| Canonical SMILES | O=C1[O-][Pt+2]2([O-]C1=O)[NH2][C@@](C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H])([2H])[C@]3([2H])[NH2]2 |
| 分子式 | C8H4D10N2O4Pt |
| 分子量 | 407.4 |
| 溶解度 | DMSO: slightly soluble,Water: slightly, sonicated |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Oxaliplatin-d10is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent.1It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively).2It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week.3Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer. 1.Alcindor, T., and Beauger, N.Oxaliplatin: A review in the era of molecularly targeted therapyCurr. Oncol.18(1)18-25(2011) 2.Rixe, O., Ortuzar, W., Alvarez, M., et al.Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panelBiochem. Pharmacol.52(12)1855-1865(1996) 3.Wang, Z., Zhou, J., Fan, J., et al.Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growthExpert Opin. Investig. Drugs18(11)1595-1604(2009) |
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