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SM-433 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SM-433 hydrochloride图片
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
SM-433 hydrochlorid 是一种 Smac 模拟物,是一种凋亡抑制蛋白 (IAPs) 的抑制剂发挥作用。SM-433 hydrochlorid 表现出强结合亲和力 XIAP BIR3 蛋白,IC50<1 μM (详细信息来自专利 WO2008128171A2)。
分子式C32H44ClN5O4
分子量598.18
溶解度DMSO : 180 mg/mL (300.91 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2)[1].

SM-433 hydrochlorid exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].

[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.