Hypoxanthine-d₄is intended for use as an internal standard for the quantification of hypoxanthine by GC- or LC-MS. Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain.¹Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice.²Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysunction, self-mutilation, and hyperuricemia.

1.Biasibetti-Brendler, H., Schmitz, F., Pierozan, P., et al.Hypoxanthine induces neuroenergetic impairment and cell death in striatum of young adult Wistar ratsMol. Neurobiol.55(5)4098-4106(2018) 2.Yong, T., Zhang, M., Chen, D., et al.Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthineJ. Ethnopharmacol.194403-411(2016)