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Necrosulfonamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Necrosulfonamide-d4图片
CAS NO:1795144-22-7
包装与价格:
包装价格(元)
500 µg电议
1mg电议

产品介绍
Necrosulfonamide-d4 是氘标记的 Necrosulfonamide。 Necrosulfonamide 是一种坏死性凋亡抑制剂,通过选择性靶向混合谱系激酶结构域样蛋白 (MLKL) 发挥作用。 Necrosulfonamide 可防止 MLKL-RIP1-RIP3 坏死小体复合物与其下游效应器相互作用。 MLKL 是 RIP3 在坏死诱导过程中的关键底物。
Cas No.1795144-22-7
Canonical SMILESO=S(NC1=NC=CN=C1OC)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])NC(C=CC3=CC=C([N+]([O-])=O)S3)=O)=O
分子式C18H11D4N5O6S2
分子量465.5
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Necrosulfonamide-d4is intended for use as an internal standard for the quantification of necrosulfonamide by GC- or LC-MS. Necrosulfonamide is an inhibitor of necroptosis, apoptosis, and pyroptosis.1,2It inhibits IL-8-induced increases in receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, mixed lineage kinase domain-like protein (MLKL), caspase-3, and caspase-8 levels, as well as IL-8-induced necroptosis and apoptosis in isolated human nucleus pulposus cells.1Necrosulfonamide binds to gasdermin D and inhibits NLRP3- and pyrin-mediated pyroptosis in mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 µM.2In vivo, necrosulfonamide (20 mg/kg) increases survival in a mouse model of LPS-induced sepsis. It also improves motor function and reduces spinal edema in a mouse model of surgically induced spinal cord injury (SCI).3

1.Zhang, Q.-X., Guo, D., Wang, F.-C., et al.Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibitionEur. Rev. Med. Pharmacol. Sci.24(5)2683-2691(2020) 2.Rathkey, J.K., Zhao, J., Liu, Z., et al.Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsisSci. Immunol.3(26)eaat2738(2018) 3.Jiao, J., Wang, Y., Ren, P., et al.Necrosulfonamide ameliorates neurological impairment in spinal cord injury by improving antioxidative capacityFront. Pharmacol.101538(2020)