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Ac-FLTD-CMK(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
An inhibitor of caspase-1, -4, -5, and -11
Canonical SMILESClCC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O.FC(F)(F)C(O)=O
分子式C26H37ClN4O8• XCF3COOH
分子量569
溶解度DMSO: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ac-FLTD-CMK is an inhibitor of caspase-1, -4, -5, and -11.1It inhibits caspase-1, -4, and -5 (IC50s = 0.0467, 1.49, and 0.329, respectively, for the recombinant human enzymes) and cleavage of gasdermin D (GSDMD), an effector involved in pyroptosis and NETosis, by mouse caspase-11 when used at a concentration of 10 µM. Ac-FLTD-CMK (10 µM) inhibits LPS- and ATP- or LPS- and nigericin-induced pyroptosis and IL-1β release in mouse bone marrow-derived macrophages (BMDMs).

1.Yang, J., Liu, Z., Wang, C., et al.Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitorProc. Natl. Acad. Sci. USA115(26)6792-6797(2018)