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10-acetyl Docetaxel
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
10-acetyl Docetaxel图片
CAS NO:125354-16-7
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
10-acetyl Docetaxel (10-Acetyl docetaxel) 是 Docetaxel 的类似物,具有抗癌活性。 Docetaxel 是一种微管分解抑制剂,具有抗有丝分裂活性。
Cas No.125354-16-7
别名多西他赛,10-Acetyl docetaxel; PNU-101383
Canonical SMILESC[C@]1(C([C@@H](C2=C(C)[C@@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C3=CC=CC=C3)=O)C[C@]4(O)C2(C)C)OC(C)=O)=O)[C@@]([C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]([C@@]6([H])C[C@@H]1O)(CO6)OC(C)=O
分子式C45H55NO15
分子量849.9
溶解度DMF: 2 mg/ml,DMSO: 3 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): insol
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

10-acetyl Docetaxel is a derivative of paclitaxel and an inhibitor of microtubule depolymerization.1It inhibits calcium-induced depolymerization of calf brain microtubule protein (MTP) in a cell-free assay when used at 20 µM. 10-acetyl Docetaxel is cytotoxic to J774.2 cells (EC50= 0.05 µM).

1.Swindell, C.S., Heerding, J.M., Krauss, N.E., et al.Characterization of the taxol structure-activity profile for the locus of the A-ring side chainBioorg. Med. Chem. Lett.4(12)1531-1536(1994)