| CAS NO: | 1217620-38-6 |
| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1217620-38-6 |
| 别名 | 生根粉263 d8 |
| Canonical SMILES | CC(C)(C1)CCC(C2=CC=C(C=C2)Cl)=C1CN3CCN(C4=CC=C(C=C4)C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(C=C5)N[C@@H](CSC6=CC=CC=C6)CCN7C([2H])([2H])C([2H])([2H])OC([2H])([2H])C7([2H])[2H])=O)=O)CC3 |
| 分子式 | C47H47ClD8F3N5O6S3 |
| 分子量 | 982.7 |
| 溶解度 | DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:2): .3mg/mL,DMSO: 25mg/mL,Ethanol: .5mg/mL |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ABT-263-d8is intended for use as an internal standard for the quantification of ABT-263 by GC- or LC-MS. ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis =<1,<0.5, and<1 nm, respectively).1It is selective for Bcl-2, Bcl-xL, and Bcl-W over Mcl-1 and A1 (Kis = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50= 0.08 µM).2ABT-263 (100 mg/kg) induces tumor regression in NCI H146 SCLC and RS4;11 acute lymphocytic leukemia (ALL) mouse xenograft models.1,3 1.Tse, C., Shoemaker, A.R., Adickes, J., et al.ABT-263: A potent and orally bioavailable Bcl-2 family inhibitorCancer Res.68(9)3421-3428(2008) 2.Bulanova, D., Ianevski, A., Bugai, A., et al.Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteinsViruses9(10)E271(2017) 3.Shoemaker, A.R., Mitten, M.J., Adickes, S., et al.Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft modelsClin. Cancer Res.14(11)3268-3277(2008) |
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