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Nicotinic acid riboside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nicotinic acid riboside图片
CAS NO:17720-18-2
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Nicotinic acid riboside 存在于人体细胞中,是一种 NAD+ 前体。Nicotinic acid riboside 是人类 NAD+ 代谢的中间体。
Cas No.17720-18-2
别名烟酸核糖
分子式C11H13NO6
分子量255.22
溶解度Water : 62.5 mg/mL (244.89 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2].

Nicotinic acid riboside (HepG2 cells; 0.01 nM~0.1 mM) helps FK866-treated cells to maintain viability at low micromolar concentrations[1]..Nicotinic acid riboside formation and release are caused by overexpression of FLAG-tagged CN-II and CN-III in HEK293 and HepG2 cells. CN-II and CN-III generate Nicotinic acid riboside in vitro by dephosphorylation of nicotinic acid mononucleotide (NAMN)[1].

[1]. Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842.
[2]. Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5’-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [published correction appears in J Biol Chem. 2010 Jan 29;285(5):3524]. J Biol Chem. 2009;284(50):34861-34869.