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SN-38 Glucuronide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SN-38 Glucuronide图片
CAS NO:121080-63-5
包装:1mg
市场价:6706元

产品介绍
SN-38 葡糖苷酸是抗癌药物伊立替康的无活性代谢物。伊立替康是一种拓扑异构酶 I 抑制剂,可用于研究结肠癌和直肠癌。
Cas No.121080-63-5
别名SN-38葡糖苷酸,SN-38G
Canonical SMILESCCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)C=C51
分子式C28H28N2O11
分子量568.5
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SN-38 Glucuronide is a phase II metabolite of irinotecan .1It is formedviaglucuronidation of the irinotecan phase I metabolite SN-38 by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1.

1.Hirose, K., Kozu, C., Yamashita, K., et al.Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 geneOncol. Lett.3(3)694-698(2012)