| CAS NO: | 93413-90-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 93413-90-2 |
| 别名 | 盐酸文拉法辛杂质D |
| Canonical SMILES | COC(C=C1)=CC=C1C(CNC)C2(O)CCCCC2.Cl |
| 分子式 | C16H25NO2 • HCl |
| 分子量 | 299.8 |
| 溶解度 | Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.1It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.2(±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).1In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg. 1.Muth, E.A., Moyer, J.A., Haskins, J.T., et al.Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxineDrug Dev. Res.23(2)191-199(1991) 2.Otton, S.V., Ball, S.E., Cheung, S.W., et al.Venlafaxine oxidation in vitro is catalysed by CYP2D6Br. J. Clin. Pharmacol.41(2)149-156(1996) |
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