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Norpropranolol(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Norpropranolol(hydrochloride)图片
CAS NO:62618-09-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An active metabolite of propranolol
Cas No.62618-09-1
Canonical SMILESOC(CN)COC1=CC=CC2=C1C=CC=C2.Cl
分子式C13H15NO2 • HCl
分子量253.7
溶解度DMSO: soluble
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Norpropranolol is an active metabolite of the β-adrenergic receptor (β-AR) antagonist propranolol .1,2It is formed from propranolol by the cytochrome P450 (CYP) isoform CYP1A2.2Norpropranolol binds to β-ARs (Kd= 42 nM in turkey erythrocytes) and inhibits (-)-isoproterenol-induced activation of adenylate cyclase with a Kivalue of 175 nM.1

1.Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E.Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclaseBiochem. Pharmacol.27(10)1445-1454(1978) 2.Masubuchi, Y., Hosokawa, S., Horie, T., et al.Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylaseDrug Metab. Dispos.22(6)909-915(1994)