| CAS NO: | 62618-09-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 62618-09-1 |
| Canonical SMILES | OC(CN)COC1=CC=CC2=C1C=CC=C2.Cl |
| 分子式 | C13H15NO2 • HCl |
| 分子量 | 253.7 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20буC |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Norpropranolol is an active metabolite of the β-adrenergic receptor (β-AR) antagonist propranolol .1,2It is formed from propranolol by the cytochrome P450 (CYP) isoform CYP1A2.2Norpropranolol binds to β-ARs (Kd= 42 nM in turkey erythrocytes) and inhibits (-)-isoproterenol-induced activation of adenylate cyclase with a Kivalue of 175 nM.1 1.Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E.Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclaseBiochem. Pharmacol.27(10)1445-1454(1978) 2.Masubuchi, Y., Hosokawa, S., Horie, T., et al.Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylaseDrug Metab. Dispos.22(6)909-915(1994) |
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