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Aripiprazole N-oxide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aripiprazole N-oxide图片
CAS NO:573691-09-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A metabolite of aripiprazole
Cas No.573691-09-5
别名阿立哌唑-N1-氧化物
Canonical SMILESO=C1NC2=CC(OCCCC[N]3(CCN(CC3)C4=C(Cl)C(Cl)=CC=C4)=O)=CC=C2CC1
分子式C23H27Cl2N3O3
分子量464.4
溶解度DMSO: soluble
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aripiprazole N-oxide is a metabolite of the atypical antipsychotic aripiprazole .1,2It is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.3Aripiprazole N-oxide is a potential impurity found in commercial preparations of aripiprazole.1

1.Filijovic, N.D., Pavlovi?, A., Nikolic, K., et al.Validation of an HPLC method for determination of aripiprazole and its impurities in pharmaceuticalsActa Chromatagr.26(1)13-28(2014) 2.Satyanarayana, B., Sumalatha, Y., Kumar, S.S., et al.Synthesis and characterization of N-oxides and metabolites of antipsychotic drug, aripiprazoleHeterocycl. Commun.11(6)485-490(2005) 3.Kubo, M., Koue, T., Inaba, A., et al.Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLEDrug Metab. Pharmacokinet.20(1)55-64(2005)