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Spirapril hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Spirapril hydrochloride图片
CAS NO:94841-17-5
包装:5mg
市场价:2790元

产品介绍
Spirapril (SCH 33844) hydrochloride 是一种有效的血管紧张素转换酶 (ACE) 抑制剂,具有降压作用。Spirapril hydrochloride 竞争性地与 ACE 结合,阻止血管紧张素I向血管紧张素 II 的转化。Spirapril hydrochloride 是螺普利拉的一种口服活性前药,可用于高血压、充血性心力衰竭的研究。
Cas No.94841-17-5
别名盐酸螺普利; SCH 33844 hydrochloride
分子式C22H31ClN2O5S2
分子量503.07
储存条件4°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1].

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]

[1]. Spirapril. Drugbank.
[2]. B Maul, et al. Alcohol consumption is controlled by angiotensin II. FASEB J