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BI8622
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BI8622图片
CAS NO:1875036-74-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
BI8622 是一种泛素连接酶 HUWE1 特异性拮抗剂,IC50 为 3.1 μM。
Cas No.1875036-74-0
分子式C25H26N6O
分子量426.51
溶解度DMSO : 125 mg/mL (293.08 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM[1].

BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC50 value of 6.8 μM in HeLa cells[1].BI8622 suppresses colony formation of Ls174T cells with estimated IC50 value of 8.4 μM[1].BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1].BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells[1].BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells[1].

[1]. Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med. 2014 Dec;6(12):1525-41.