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(±)9(10)-DiHOME
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)9(10)-DiHOME图片
CAS NO:263399-34-4
包装与价格:
包装价格(元)
25μg电议
50μg电议
100μg电议
500μg电议

产品介绍
(±)9(10)-DiHOME 是 9,10-DiHOME 的外消旋体。
Cas No.263399-34-4
别名(±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸
Canonical SMILESO[C@H](C/C=C\CCCCC)[C@@H](O)CCCCCCCC(O)=O
分子式C18H34O4
分子量314.5
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 µ g/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst. This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME. Mitochondrial dysfunction, vasodilation, and apoptosis are features of leukotoxin toxicity. In renal proximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death.