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(±)-Muscarine(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Muscarine(hydrate)图片
CAS NO:2241280-55-5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An agonist of muscarinic acetylcholine receptors
Cas No.2241280-55-5
Canonical SMILESC[C@@H]1[C@@H](O)C[C@H](C[N+](C)(C)C)O1.[Cl-].O
分子式C9H20NO2.Cl [XH2O]
分子量174.3
溶解度Water: 50 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(±)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found inA. muscaria.1It induces spasms in isolated intestinal ileum from mouse, guinea pig, rabbit, dog, monkey, and horse, contraction of longitudinal uterine and bladder muscle strips from mouse, guinea pig, rabbit, rat, horse, and dog, and slows the heart rate of isolated guinea pig and rabbit atria.In vivo, (±)-muscarine induces bronchoconstriction in guinea pigs and rabbits as well as respiratory depression in rabbits and cats with minimum active doses (MADs) ranging from 1 to 5 μg/kg. It reduces blood pressure in cats, dogs, and rabbits and induces uterine, bladder, and intestinal contraction in cats and dogs. (±)-Muscarine (0.005-0.01 mg/kg) increases circling and pacing behaviors and induces fear aggression in cats.2It has antinociceptive activity in rats in the hot plate and tail-flick tests.3(±)-Muscarine also inhibits acetylcholinesterase (Ki= 220 μM).4

1.Fraser, P.J.Pharmacological actions of pure muscarine chlorideBr. J. Pharmacol. Chemother.12(1)47-52(1957) 2.Beleslin, D.B., and Samardzi?, R.Muscarine- and carbachol-induced aggressions: Fear and irritable kinds of aggressionsPyschopharmacology (Berl.)55(3)233-236(1977) 3.Iwamoto, E.T., and Marion, L.Characterization of the antinociception produced by intrathecally administered muscarinic agonists in ratsJ. Pharmacol. Exp. Ther.266(1)329-338(1993) 4.Witkop, B., Durant, R.C., and Friess, S.L.Acetylcholinesterase inhibitory activities of muscarine and muscarone derivativesExperientia15(8)300-301(1959)