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FR054
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FR054图片
CAS NO:35954-65-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
FR054 是 HBO 酶 PGM3 的抑制剂,具有明显的抗乳腺癌活性。
Cas No.35954-65-5
分子式C14H19NO8
分子量329.3
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1].

FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects[1].FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells[1].FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death[1].

FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice[1].

[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.