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CGP 77675(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CGP 77675(hydrate)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An inhibitor of Src family kinases
Canonical SMILESOC1CCN(CCC2=CC=C(N3C4=NC=NC(N)=C4C(C5=CC=CC(OC)=C5)=C3)C=C2)CC1.O
分子式C26H29N5O2·XH2O
分子量443.5
溶解度DMSO: 10 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively).1It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50values.1,2,3CGP 77675 is used to elucidate the role of SFKs in such processes as bone resorption, tight junction formation in epithelial cells, and allograft survival.2,1,4It can also be used in combination with the GSK3 inhibitor CHIR99021 to maintain mouse embryonic stem cells.5

1.Missbach, M., Jeschke, M., Feyen, J., et al.A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivoBone24(5)437-449(1999) 2.Chen, Y.-H., Goodenough, D.A., and Jeansonne, B.Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cellsMol. Biol. Cell13(4)1227-1237(2002) 3.šuša, M., Luong-Nguyen, N.-H., Crespo, J., et al.Active recombinant human tyrosine kinase c-Yes: expression in baculovirus system, purification, comparison to c-Src, and inhibition by a c-Src inhibitorProtein Expr. Purif.19(1)99-106(2000) 4.Zhang, Q., Fairchild, R.L., Reich, M.B., et al.Inhibition of Src kinases combined with CD40 ligand blockade prolongs murine cardiac allograft survivalTransplantation80(8)1112-1120(2005) 5.Shimizu, T., Ueda, J., Ho, J.C., et al.Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signalingStem Cells30(7)1394-1404(2012)