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GSK-A1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GSK-A1图片
CAS NO:1416334-69-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
GSK-A1 是一种选择性 III 型磷脂酰肌醇 4-激酶 PI4KA (PI4KIIIα) 抑制剂，pIC50 为 8.5-9.8。
Cas No.1416334-69-4
Canonical SMILESO=S(NC1=C(F)C=CC=C1)(C2=C(OC)N=CC(C3=CC4=C(N=C(N4C5=CC=C(N6CCOCC6)C=C5)N)C=C3)=C2)=O
分子式C29H27FN6O4S
分子量574.6
溶解度DMSO: 2 mg/ml
储存条件Store at -20°
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC50= 3.16 nM).1It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC50s = >50 nM) but also inhibits PI3Kγ (IC50= 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50= 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.

1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)