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Cl-Necrostatin-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cl-Necrostatin-1图片
CAS NO:862377-51-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A RIPK1 inhibitor
Cas No.862377-51-3
Canonical SMILESO=C(C(N1)CC2=CNC3=C(Cl)C=CC=C32)N(C)C1=S
分子式C13H12ClN3OS
分子量293.8
溶解度DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 14 mg/ml,Ethanol: 3 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1).1It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 µM. It also inhibits TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50= 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling.2,3Cl-Necrostatin-1 (2 µl of a 4 mM solution, i.c.v.) reduces infarct size when administered pre- and post-occlusion, or post-occlusion only, in a mouse model of middle cerebral artery occlusion (MCAO).

1.Degterev, A., Hitomi, J., Germscheid, M., et al.Identification of RIP1 kinase as a specific cellular target of necrostatinsNat. Chem. Biol.4(5)313-321(2008) 2.Teng, X., Degterev, A., Jagtap, P., et al.Structure-activity relationship study of novel necroptosis inhibitorsBioorg. Med. Chem. Lett.15(22)5039-5044(2005) 3.Degterev, A., Huang, Z., Boyce, M., et al.Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injuryNat. Chem. Biol.1(2)112-119(2005)