| CAS NO: | 1262857-73-7 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1262857-73-7 |
| 分子式 | C21H19F4N5O2 |
| 分子量 | 449.4 |
| 溶解度 | DMSO : 250 mg/mL (556.30 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)[1] NB-360 is a potent, brain penetrable, and orally bioavailable dualBACE1/BACE2inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2]. |
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