Basiliximab

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Basiliximab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	179045-86-4
包装:	5mg
市场价:	13050元

产品介绍

Basiliximab (CHI 621) 是一种重组嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 抗体。Basiliximab 可用于肾移植研究。

Cas No.

179045-86-4

别名

CHI 621

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptorantibody. Basiliximab can be used for the research of renal transplantation^[1].

Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα^[1].
Basiliximab binds only to activated lymphocytes and macrophages/monocytes^[3].
Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα^[3].

Basiliximab (CHI 621) (0.07 mg/rat; i.v.; once) decreases total placental natural killer cells in reduced uterine perfusion pressure (RUPP) rats^[2].

Animal Model:	Timed-pregnant Sprague Dawley (SD) rats, reduced uterine perfusion pressure (RUPP) rat model of placental ischemia^[2]
Dosage:	0.07 mg/rat
Administration:	IV infusion, once
Result:	Decreased total placental natural killer cells. Had no effect to lower MAP or improve pup weight and placental weight.